Phosphorylation and hetero‐oligomerization regulate the dopamine D3 receptor/adenylyl cyclase type 5 signaling complex
نویسندگان
چکیده
منابع مشابه
Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors.
The D2-like dopamine receptors couple to a variety of signal transduction pathways, including inhibition of adenylate cyclase, mitogenesis, and activation of potassium channels. Although these effects are mediated via pertussis toxin-sensitive G proteins, G(i/o), it is likely that some of these effects are influenced by the release of G protein betagamma subunits. Type II adenylate cyclase (ACI...
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چکیده ندارد.
Abnormalities of Dopamine D3 Receptor Signaling in the Diseased Brain
Dopamine D3 receptors (D3R) modulate neuronal activity in several brain regions including cortex, striatum, cerebellum, and hippocampus. A growing body of evidence suggests that aberrant D3R signaling contributes to multiple brain diseases, such as Parkinson's disease, essential tremor, schizophrenia, and addiction. In line with these findings, D3R has emerged as a potential target in the treat...
متن کاملStructure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.
Dopamine modulates movement, cognition, and emotion through activation of dopamine G protein-coupled receptors in the brain. The crystal structure of the human dopamine D3 receptor (D3R) in complex with the small molecule D2R/D3R-specific antagonist eticlopride reveals important features of the ligand binding pocket and extracellular loops. On the intracellular side of the receptor, a locked co...
متن کاملACCELERATED COMMUNICATION Activation of Type II Adenylate Cyclase by D2 and D4 but Not D3 Dopamine Receptors
The D2-like dopamine receptors couple to a variety of signal transduction pathways, including inhibition of adenylate cyclase, mitogenesis, and activation of potassium channels. Although these effects are mediated via pertussis toxin-sensitive G proteins, Gi/o, it is likely that some of these effects are influenced by the release of G protein bg subunits. Type II adenylate cyclase (ACII) is hig...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.831.1